2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

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Aldehyde Dehydrogenases (ALDHs) are a superfamily of NADP+-dependent enzymes that metabolize endogenous and exogenous aldehydes to corresponding carboxylic acids. This superfamily of proteins is comprised of 19 isozymes, with constitutive activity of at least one isozyme observed in a majority of mammalian tissues. The ALDHs play important roles, among other things, in cellular detoxification, the protection against ultraviolet radiation-induced damage, and amino acid metabolism.

The ALDH1A subfamily plays a pivotal role in embryogenesis and development by mediating retinoic acid signaling. ALDH2, as a key enzyme that oxidizes acetaldehyde, is crucial for alcohol metabolism. ALDH1A1 and ALDH3A1 are lens and corneal crystallins, which are essential elements of the cellular defense mechanism against ultraviolet radiation-induced damage in ocular tissues. Many ALDH isozymes are important in oxidizing reactive aldehydes derived from lipid peroxidation and thereby help maintain cellular homeostasis. Increased expression and activity of ALDH isozymes have been reported in various human cancers and are associated with cancer relapse. As a direct consequence of their significant physiological and toxicological roles, inhibitors of the ALDH enzymes have been developed to treat human diseases.

Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

Aldehyde Dehydrogenase (ALDH) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139031
    ALDH1A2-IN-1
    		Inhibitor 98.80%
    ALDH1A2-IN-1 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.91 μM; Kd=0.26 μM) with several hydrophobic interactions.
    ALDH1A2-IN-1
  • HY-126241
    RV01
    		Inhibitor 98.0%
    RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity. RV01 decreases iNOS expression, with anti-neuroinflammatory activity.
    RV01
  • HY-N1177
    Taraxerone
    		Inhibitor ≥98.0%
    Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC50 values of 512.42 and 500.16 μM, respectively.
    Taraxerone
  • HY-W207195
    7-Hydroxy-4-phenylcoumarin
    		Inhibitor
    7-Hydroxy-4-phenylcoumarin is a dual ALDH-2 and MAO inhibitor, with IC50 values of 1.5 and 0.5 µM, respectively.
    7-Hydroxy-4-phenylcoumarin
  • HY-N7083R
    Citral (Standard)
    		Inhibitor
    Citral (Standard) is the analytical standard of Citral. This product is intended for research and analytical applications. Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects.
    Citral (Standard)
  • HY-169884
    MCI-INI-3
    		Inhibitor ≥99.0%
    MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3 (with a Ki value of 0.55 μM for ALDH1A3 and a Ki value of 78.2 μM for ALDH1A1). MCIINI-3 inhibits the biosynthesis of retinoic acid and reduces the viability of GSC-83 and GSC-326 glioblastoma cells.
    MCI-INI-3
  • HY-168985
    Mirivadelgat
    		Activator
    Mirivadelgat is an activator of aldehyde dehydrogenase 2 activator. Mirivadelgat is promising for research of interstitial lung disease-pulmonary hypertension and cancers.
    Mirivadelgat
  • HY-RS00570
    Aldh2 Rat Pre-designed siRNA Set A
    		Inhibitor

    Aldh2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aldh2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Aldh2 Rat Pre-designed siRNA Set A
    Aldh2 Rat Pre-designed siRNA Set A
  • HY-159111
    KS124
    		Inhibitor
    KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production.
    KS124
  • HY-121970
    iGP-1
    		Inhibitor
    iGP-1 is a selective and cell-permeant mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor. iGP-1 inhibits H2O2 production by mGPDH.
    iGP-1
  • HY-157872
    ALDH1A1-IN-4
    		Inhibitor
    ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, with IC50 value of 0.32 μM. ALDH1A1-IN-4 plays an important role in cancer research.
    ALDH1A1-IN-4
  • HY-158026
    ALDH1A1-IN-5
    		Inhibitor
    ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC50 value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC).
    ALDH1A1-IN-5
  • HY-RS00568
    ALDH2 Human Pre-designed siRNA Set A
    		Inhibitor

    ALDH2 Human Pre-designed siRNA Set A contains three designed siRNAs for ALDH2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    ALDH2 Human Pre-designed siRNA Set A
    ALDH2 Human Pre-designed siRNA Set A
  • HY-76006R
    3-Hydroxybenzaldehyde (Standard)
    3-Hydroxybenzaldehyde (Standard) is the analytical standard of 3-Hydroxybenzaldehyde. This product is intended for research and analytical applications. 3-Hydroxybenzaldehyde (3-HBA) is a precursor compound for phenolic compounds like Protocatechuic aldehyde (PCA) (HY-N0295). 3-Hydroxybenzaldehyde, produced by 3-hydroxybenzyl-alcohol dehydrogenase, is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans. 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo. 3-Hydroxybenzaldehyde is proming for research of atherosclerosis[1][2][3][4].
    3-Hydroxybenzaldehyde (Standard)
  • HY-139032
    CM121
    		Inhibitor
    CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions.
    CM121
  • HY-122373
    Coprine
    		Inhibitor
    Coprine is a mycotoxin isolated from Coprinopsis atramentaria. Coprine is an acetaldehyde dehydrogenase inhibitor that causes the buildup of acetaldehyde, causing the alcohol flushing reaction.
    Coprine
  • HY-RS00569
    Aldh2 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Aldh2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aldh2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Aldh2 Mouse Pre-designed siRNA Set A
    Aldh2 Mouse Pre-designed siRNA Set A
  • HY-142708
    α-Pyridoin
    		Inhibitor
    α-Pyridoin is a unique enediol antioxidant.
    α-Pyridoin
  • HY-N11451
    Lacto-N-fucopentaose III
    		Activator
    Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.
    Lacto-N-fucopentaose III
  • HY-158268
    4-Hydroxynonenal/BSA
    		Inhibitor
    4-Hydroxynonenal/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-Hydroxynonenal/BSA
Cat. No. Product Name / Synonyms Application Reactivity
Aldehyde Dehydrogenase (ALDH) Isoform Comparison

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