2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)

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Aldehyde Dehydrogenases (ALDHs) are a superfamily of NADP+-dependent enzymes that metabolize endogenous and exogenous aldehydes to corresponding carboxylic acids. This superfamily of proteins is comprised of 19 isozymes, with constitutive activity of at least one isozyme observed in a majority of mammalian tissues. The ALDHs play important roles, among other things, in cellular detoxification, the protection against ultraviolet radiation-induced damage, and amino acid metabolism.

The ALDH1A subfamily plays a pivotal role in embryogenesis and development by mediating retinoic acid signaling. ALDH2, as a key enzyme that oxidizes acetaldehyde, is crucial for alcohol metabolism. ALDH1A1 and ALDH3A1 are lens and corneal crystallins, which are essential elements of the cellular defense mechanism against ultraviolet radiation-induced damage in ocular tissues. Many ALDH isozymes are important in oxidizing reactive aldehydes derived from lipid peroxidation and thereby help maintain cellular homeostasis. Increased expression and activity of ALDH isozymes have been reported in various human cancers and are associated with cancer relapse. As a direct consequence of their significant physiological and toxicological roles, inhibitors of the ALDH enzymes have been developed to treat human diseases.

Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

Aldehyde Dehydrogenase (ALDH) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118980
    Sorbitol dehydrogenase-IN-1
    		Inhibitor 98.70%
    Sorbitol dehydrogenase-IN-1 is a potent and orally active sorbitol dehydrogenase inhibitor with IC50 s of 4, 5 nM for rat and human, respectively. Sorbitol Dehydrogenase (SDH) is an enzyme that belongs to the zinc-containing alcohol dehydrogenase (ADH) family. ADH and ALDH are enzymes that work together to metabolize alcohol.
    Sorbitol dehydrogenase-IN-1
  • HY-139031
    ALDH1A2-IN-1
    		Inhibitor 98.80%
    ALDH1A2-IN-1 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.91 μM; Kd=0.26 μM) with several hydrophobic interactions.
    ALDH1A2-IN-1
  • HY-126241
    RV01
    		Inhibitor 98.0%
    RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity. RV01 decreases iNOS expression, with anti-neuroinflammatory activity.
    RV01
  • HY-N1177
    Taraxerone
    		Inhibitor ≥98.0%
    Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC50 values of 512.42 and 500.16 μM, respectively.
    Taraxerone
  • HY-159111
    KS124
    		Inhibitor
    KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production.
    KS124
  • HY-121970
    iGP-1
    		Inhibitor
    iGP-1 is a selective and cell-permeant mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor. iGP-1 inhibits H2O2 production by mGPDH.
    iGP-1
  • HY-157872
    ALDH1A1-IN-4
    		Inhibitor
    ALDH1A1-IN-4 (compound A1) is a potent inhibitor of aldehyde dehydrogenase (ALDH) A1, with IC50 value of 0.32 μM. ALDH1A1-IN-4 plays an important role in cancer research.
    ALDH1A1-IN-4
  • HY-158026
    ALDH1A1-IN-5
    		Inhibitor
    ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC50 value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC).
    ALDH1A1-IN-5
  • HY-139032
    CM121
    		Inhibitor
    CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions.
    CM121
  • HY-122373
    Coprine
    		Inhibitor
    Coprine is a mycotoxin isolated from Coprinopsis atramentaria. Coprine is an acetaldehyde dehydrogenase inhibitor that causes the buildup of acetaldehyde, causing the alcohol flushing reaction.
    Coprine
  • HY-142708
    α-Pyridoin
    		Inhibitor
    α-Pyridoin is a unique enediol antioxidant.
    α-Pyridoin
  • HY-N11451
    Lacto-N-fucopentaose III
    		Activator
    Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation.
    Lacto-N-fucopentaose III
  • HY-158268
    4-Hydroxynonenal/BSA
    		Inhibitor
    4-Hydroxynonenal/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    4-Hydroxynonenal/BSA
  • HY-146240
    ALDH1A1-IN-3
    		Inhibitor
    ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement.
    ALDH1A1-IN-3
  • HY-134917
    Aldi-2
    		Inhibitor
    Aldi-2 is a potent and specific covalent inhibitor of aldehyde dehydrogenases (ALDHs) with IC50s of 2.5, 6.4 and 1.9 μM against ALDH1A1, ALDH2 and ALDH3A1, respectively. Aldi-2 can be utilized in cancer research.
    Aldi-2
  • HY-113734
    CM026
    		Inhibitor
    CM026 is a selective aldehyde dehydrogenase 1A1 inhibitor with submicromolar inhibitory activity against aldehyde dehydrogenase 1A1. Its inhibitory mechanism is related to binding to the aldehyde binding pocket and utilizing a unique glycine residue. It can be used as a chemical tool to study the role of this enzyme in disease.
    CM026
  • HY-148617
    ALDH2 modulator 1
    		Modulator
    ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice.
    ALDH2 modulator 1
  • HY-18768A
    NCT-501 hydrochloride
    		Inhibitor
    NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).
    NCT-501 hydrochloride
  • HY-144671
    ALDH3A1-IN-2
    		Inhibitor
    ALDH3A1-IN-2 (Compound 19) is a potent inhibitor of ALDH3A1 with an IC50 of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH3A1-IN-2 has the potential for the research of cancer diseases.
    ALDH3A1-IN-2
  • HY-B0364AR
    Dyclonine (hydrochloride) (Standard)
    		Inhibitor
    Dyclonine (hydrochloride) (Standard) is the analytical standard of Dyclonine (hydrochloride). This product is intended for research and analytical applications. Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain.
    Dyclonine (hydrochloride) (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Aldehyde Dehydrogenase (ALDH) Isoform Comparison

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